Equilibrium Studies on the Formaldehyde Reaction with Native DNA
نویسندگان
چکیده
منابع مشابه
Formaldehyde as a probe of DNA structure. r. Mechanism of the initial reaction of Formaldehyde with DNA.
Formaldehyde is used as a probe of the dynamic behavior of native DNA. We first show experimentally how initial denaturation rates vary with temperature, formaldehyde concentration, DNA melting temperature, and DNA molecular weight. Electron microscopy of DNA from the initial phases of the reaction verifies that denaturation initiates a t AT-rich regions in the interior of the DNA molecule. The...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1976
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1976.tb10204.x